Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1992;12:682-690

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rainwater, D. L.
Right arrow Articles by VandeBerg, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rainwater, D. L.
Right arrow Articles by VandeBerg, J. L.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHOLESTEROL

Arteriosclerosis and Thrombosis, Vol 12, 682-690, Copyright © 1992 by American Heart Association

ARTICLES

A DNA polymorphism for LCAT is associated with altered LCAT activity and high density lipoprotein size distributions in baboons

DL Rainwater, J Blangero, JE Hixson, S Birnbaum, GE Mott and JL VandeBerg
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.

A polymorphic Pvu II site was mapped to intron 5 of LCAT, the gene encoding baboon lecithin: cholesterol acyltransferase (LCAT). In a study of 83 baboons, heterozygous baboons (Pv1/Pv2) had significantly higher LCAT enzyme activity levels than did baboons homozygous for the more common allele (Pv1/Pv1). LCAT genotype explained 6% of the total variation in LCAT enzyme activity. To test for allelic effects on cholesterol metabolism, we compared serum concentrations of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I). We also compared distributions of cholesterol and apo A-I among three HDL size classes (HDL1, HDL2, and HDL3). All measurements were obtained for each baboon after long-term feeding of a basal diet low in cholesterol and fat and again after 7 weeks on an atherogenic diet. Heterozygous baboons had significantly lower serum levels of total cholesterol than did homozygotes. In addition, we detected significant effects of LCAT genotype on size distributions of HDL cholesterol and apo A-I on both diets but did not detect any genotype-by-diet interaction. Heterozygotes had increased amounts of cholesterol and apo A-I in HDL3 particles and lower amounts of cholesterol and apo A-I in the larger HDL size classes by comparison with homozygotes. Overall, the LCAT polymorphism explained a significant proportion of total variation in cholesterol (4-10%) and apo A-I (13%) distributions on both diets. Thus, the results indicate that the LCAT polymorphism is associated with significant differences in LCAT enzyme activity and with alterations in HDL compositions.


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
B. Kaess, M. Fischer, A. Baessler, K. Stark, F. Huber, W. Kremer, H. R. Kalbitzer, H. Schunkert, G. Riegger, and C. Hengstenberg
The lipoprotein subfraction profile: heritability and identification of quantitative trait loci
J. Lipid Res., April 1, 2008; 49(4): 715 - 723.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. C. Mahaney, J. Blangero, D. L. Rainwater, G. E. Mott, A. G. Comuzzie, J. W. MacCluer, and J. L. VandeBerg
Pleiotropy and Genotype by Diet Interaction in a Baboon Model for Atherosclerosis : A Multivariate Quantitative Genetic Analysis of HDL Subfractions in Two Dietary Environments
Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 1134 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. L. Rainwater, C. M. Kammerer, J. E. Hixson, K. D. Carey, K. S. Rice, B. Dyke, J. F. VandeBerg, S. H. Slifer, L. D. Atwood, H. C. McGill Jr, et al.
Two Major Loci Control Variation in ß-Lipoprotein Cholesterol and Response to Dietary Fat and Cholesterol in Baboons
Arterioscler. Thromb. Vasc. Biol., July 1, 1998; 18(7): 1061 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. L. Rainwater, B. D. Mitchell, M. C. Mahaney, and S. M. Haffner
Genetic Relationship Between Measures of HDL Phenotypes and Insulin Concentrations
Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3414 - 3419.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. G. Comuzzie, D. L. Rainwater, J. Blangero, M. C. Mahaney, J. L. VandeBerg, and J. W. MacCluer
Shared and Unique Genetic Effects Among Seven HDL Phenotypes
Arterioscler. Thromb. Vasc. Biol., May 1, 1997; 17(5): 859 - 864.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. T.K. Singh, D. L. Rainwater, S. M. Haffner, J. L. VandeBerg, W. R. Shelledy, P. H. Moore Jr, and T. D. Dyer
Effect of Diabetes on Lipoprotein Size
Arterioscler. Thromb. Vasc. Biol., November 1, 1995; 15(11): 1805 - 1811.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. L. Rainwater, M. J. Ludwig, S. M. Haffner, and J. L. VandeBerg
Lipid and Lipoprotein Factors Associated With Variation in Lp(a) Density
Arterioscler. Thromb. Vasc. Biol., March 1, 1995; 15(3): 313 - 319.
[Abstract] [Full Text]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1992 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.