Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1992;12:163-171

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baldwin, A. L.
Right arrow Articles by Simon, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baldwin, A. L.
Right arrow Articles by Simon, B. R.

Arteriosclerosis and Thrombosis, Vol 12, 163-171, Copyright © 1992 by American Heart Association

ARTICLES

Effect of pressure on aortic hydraulic conductance

AL Baldwin, LM Wilson and BR Simon
Department of Physiology, University of Arizona, Tucson 85724.

This study was performed to determine whether the transmural hydraulic conductance (Lp) of the rabbit aortic wall depends on its distension. In 19 rabbits, the aorta was cannulated in situ and perfused at a given pressure with a physiologically buffered solution containing 4% bovine serum albumin. The output cannula was then occluded to limit fluid flow to that traversing the artery wall. External diameter and transmural fluid flow were measured at three pressures (eight rabbits, group 1) or at four pressures (12 rabbits, group 2) in each vessel. Transmural fluid flow was determined by monitoring the velocity of an air bubble within a buffer-filled tube leading to the input cannula. From group 1 measurements, Lp values (mean +/- SD) at 50, 100, and 150 mm Hg were calculated to be 3.8 +/- 2.8, 3.5 +/- 1.3, and 4.1 +/- 1.2 x 10(-8) cm/sec/mm Hg, respectively. Group 2 measurements gave values of 4.2 +/- 1.6, 3.8 +/- 1.1, 3.8 +/- 1.1, and 4.2 +/- 1.1 x 10(-8) cm/sec/mm Hg at 75, 100, 125, and 150 mm Hg, respectively. Paired Student's t tests indicated no significant change in Lp with pressure. However, linear regression analysis demonstrated a weak correlation between Lp values obtained at 50 and 100 mm Hg (r2 = 0.30) and at 75 and 100 mm Hg (r2 = 0.36). Values of Lp at 100 and 150 mm Hg and at 125 and 150 mm Hg were closely correlated in each case. These results suggest that between 50 and 100 mm Hg the structural properties of the aortic wall change so as to alter Lp but not in the same way in each vessel. Lp may increase or decrease depending on which structural change predominates in a particular vessel.


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J.-B. Michel, O. Thaunat, X. Houard, O. Meilhac, G. Caligiuri, and A. Nicoletti
Topological Determinants and Consequences of Adventitial Responses to Arterial Wall Injury
Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1259 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Shou, K.-m. Jan, and D. S. Rumschitzki
Transport in rat vessel walls. I. Hydraulic conductivities of the aorta, pulmonary artery, and inferior vena cava with intact and denuded endothelia
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2758 - H2771.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M.-h. Kim, N. R. Harris, and J. M. Tarbell
Regulation of hydraulic conductivity in response to sustained changes in pressure
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2551 - H2558.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. P. Alberding, A. L. Baldwin, J. K. Barton, and E. Wiley
Effects of pulsation frequency and endothelial integrity on enhanced arterial transmural filtration produced by pulsatile pressure
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H931 - H937.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. P. Alberding, A. L. Baldwin, J. K. Barton, and E. Wiley
Onset of pulsatile pressure causes transiently increased filtration through artery wall
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1827 - H1835.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Civelek, K. Ainslie, J. S. Garanich, and J. M. Tarbell
Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism
J Appl Physiol, December 1, 2002; 93(6): 1907 - 1917.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. E. Mullick, B. A. Walsh, K. M. Reiser, and J. C. Rutledge
Chronic estradiol treatment attenuates stiffening, glycoxidation, and permeability in rat carotid arteries
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2204 - H2210.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Tarbell, L. Demaio, and M. M. Zaw
Effect of pressure on hydraulic conductivity of endothelial monolayers: role of endothelial cleft shear stress
J Appl Physiol, July 1, 1999; 87(1): 261 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. L. Baldwin, L. M. Wilson, I. Gradus-Pizlo, R. Wilensky, and K. March
Effect of Atherosclerosis on Transmural Convection and Arterial Ultrastructure : Implications for Local Intravascular Drug Delivery
Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3365 - 3375.
[Abstract] [Full Text]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1992 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.