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Arteriosclerosis, Thrombosis, and Vascular Biology. 1992;12:78-82

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Arteriosclerosis and Thrombosis, Vol 12, 78-82, Copyright © 1992 by American Heart Association

ARTICLES

Monocytes may amplify their recruitment into inflammatory lesions by inducing monocyte chemotactic protein

SD Cushing and AM Fogelman
Department of Medicine, UCLA School of Medicine 90024-1679.

By Northern analysis, freshly isolated monocytes contained no detectable mRNA for monocyte chemotactic protein-1 (MCP-1). However, after 4 hours of incubation at 37 degrees C, MCP-1 mRNA was clearly induced in the monocytes and was found to be highly dependent and directly proportional to the monocyte density. The level of MCP-1 mRNA continued to increase, reaching a peak after 22 hours of incubation. After 3 days in culture, MCP-1 mRNA levels had declined substantially and after 8 days were undetectable in the monocytes/macrophages. The amount of MCP-1 protein secreted correlated with the density-dependent increase in MCP-1 message. We hypothesize that the migration of monocytes into inflammatory lesions may be amplified by the density and time-dependent induction of MCP-1.


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