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Arteriosclerosis, Thrombosis, and Vascular Biology. 1991;11:1315-1321

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Arteriosclerosis and Thrombosis, Vol 11, 1315-1321, Copyright © 1991 by American Heart Association

ARTICLES

Effects of human recombinant macrophage colony-stimulating factor on the secretion of lipoprotein lipase from macrophages

N Mori, T Gotoda, S Ishibashi, H Shimano, K Harada, T Inaba, F Takaku, Y Yazaki and N Yamada
Third Department of Internal Medicine, University of Tokyo, Hongo, Japan.

The effects of human recombinant macrophage colony-stimulating factor (M-CSF) on the secretion of lipoprotein lipase were studied in rat alveolar macrophages. Five nanograms per milliliter M-CSF significantly enhanced lipoprotein lipase secretion (threefold), and the maximal effect (10-fold) of M-CSF on lipoprotein lipase secretion was observed at a dose of 200 ng/ml M-CSF. The effect of M-CSF was time dependent but was not manifested during the first 8 hours of incubation. After 24 hours, its effects were evident and dose dependent. On blot hybridization of macrophage RNAs with human cDNA of lipoprotein lipase, a remarkable and dose-dependent increase in mRNA level (7.3-fold) was found in M-CSF-treated alveolar macrophages. The secretion of lipoprotein lipase was also enhanced in human monocyte-derived macrophages (2.6-fold), whereas the secretion from either THP-1 cells, P388 cells, or J774 cells was not significantly enhanced. These results indicate that the stimulation of lipoprotein lipase secretion after M- CSF treatment was evident in rat alveolar macrophages and human monocyte-derived macrophages on the basis of both enzyme activity and mRNA level; therefore, M-CSF may be involved in lipoprotein metabolism of macrophages through modulation of the secretion of lipoprotein lipase.


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