Arteriosclerosis and Thrombosis, Vol 11, 797-804, Copyright © 1991 by American Heart Association

ARTICLES

Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables

R McPherson, CJ Mann, AR Tall, M Hogue, L Martin, RW Milne and YL Marcel
Lipid Research Laboratory, Royal Victoria Hospital, McGill University, Montreal, Canada.

Cholesteryl ester transfer protein (CETP) mediates an important pathway for reverse cholesterol transport. Concentrations of CETP in fasting plasma were measured by radioimmunoassay in two different groups of hyperlipoproteinemic subjects. Plasma CETP concentrations measured by radioimmunoassay correlated closely with cholesterol ester transfer activity in normal plasma (r = 0.86). In the first group of 58 patients, plasma CETP concentrations were significantly increased, as compared with those in 79 normal subjects and in hypercholesterolemic (+26%) and combined hyperlipoproteinemic (+25%) subjects but were not altered in moderately hypertriglyceridemic subjects. Marked elevations in plasma CETP levels were documented in patients with dysbetalipoproteinemia (+68%) and severe chylomicronemia (+85%). Similar results were obtained in a second population of 50 hyperlipoproteinemic subjects. Significant correlations were found between plasma CETP levels and total cholesterol (r = 0.52), very low density lipoprotein (VLDL) cholesterol (r = 0.63), and apolipoprotein E concentration (r = 0.40). Correction of the lipoprotein phenotype by dietary means resulted in significant reductions in plasma CETP concentrations in patients with chylomicronemia and dysbetalipoproteinemia. In these subjects, plasma high density lipoprotein cholesterol concentrations increased as CETP decreased. These studies indicate that CETP levels increase in association with enhanced peripheral cholesterol transport via low density lipoprotein, beta-VLDL, or chylomicron remnants.

This article has been cited by other articles:

				L. Izem and R. E. Morton Molecular cloning of hamster lipid transfer inhibitor protein (apolipoprotein F) and regulation of its expression by hyperlipidemia J. Lipid Res., April 1, 2009; 50(4): 676 - 684. [Abstract] [Full Text] [PDF]

				G. Catalano, Z. Julia, E. Frisdal, B. Vedie, N. Fournier, W. Le Goff, M. J. Chapman, and M. Guerin Torcetrapib Differentially Modulates the Biological Activities of HDL2 and HDL3 Particles in the Reverse Cholesterol Transport Pathway Arterioscler Thromb Vasc Biol, February 1, 2009; 29(2): 268 - 275. [Abstract] [Full Text] [PDF]

				S. E. Borggreve, H. L. Hillege, G. M. Dallinga-Thie, P. E. de Jong, B. H.R. Wolffenbuttel, D. E. Grobbee, A. van Tol, R. P.F. Dullaart, and on behalf of the PREVEND Study Group High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides Eur. Heart J., April 4, 2007; (2007) ehm062v1. [Abstract] [Full Text] [PDF]

				M. Westerterp, C. C. van der Hoogt, W. de Haan, E. H. Offerman, G. M. Dallinga-Thie, J. W. Jukema, L. M. Havekes, and P. C.N. Rensen Cholesteryl Ester Transfer Protein Decreases High-Density Lipoprotein and Severely Aggravates Atherosclerosis in APOE*3-Leiden Mice Arterioscler Thromb Vasc Biol, November 1, 2006; 26(11): 2552 - 2559. [Abstract] [Full Text] [PDF]

				H. Zhou, Z. Li, M. R. Hojjati, D. Jang, T. P. Beyer, G. Cao, A. R. Tall, and X.-C. Jiang Adipose tissue-specific CETP expression in mice: impact on plasma lipoprotein metabolism J. Lipid Res., September 1, 2006; 47(9): 2011 - 2019. [Abstract] [Full Text] [PDF]

				P. J. Barter and J. J.P. Kastelein Targeting Cholesteryl Ester Transfer Protein for the Prevention and Management of Cardiovascular Disease J. Am. Coll. Cardiol., February 7, 2006; 47(3): 492 - 499. [Abstract] [Full Text] [PDF]

				E. Frisdal, A. H.E.M. Klerkx, W. L. Goff, M. W.T. Tanck, J.-P. Lagarde, J. W. Jukema, J. J.P. Kastelein, M. J. Chapman, and M. Guerin Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study Hum. Mol. Genet., September 15, 2005; 14(18): 2607 - 2618. [Abstract] [Full Text] [PDF]

				G. J. de Grooth, A. H. E. M. Klerkx, E. S. G. Stroes, A. F. H. Stalenhoef, J. J. P. Kastelein, and J. A. Kuivenhoven A review of CETP and its relation to atherosclerosis J. Lipid Res., November 1, 2004; 45(11): 1967 - 1974. [Abstract] [Full Text] [PDF]

				S. M. Boekholdt, J.-A. Kuivenhoven, N. J. Wareham, R. J.G. Peters, J. W. Jukema, R. Luben, S. A. Bingham, N. E. Day, J. J.P. Kastelein, and K.-T. Khaw Plasma Levels of Cholesteryl Ester Transfer Protein and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The Prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk Population Study Circulation, September 14, 2004; 110(11): 1418 - 1423. [Abstract] [Full Text] [PDF]

				C. C. Schwartz, J. M. VandenBroek, and P. S. Cooper Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans J. Lipid Res., September 1, 2004; 45(9): 1594 - 1607. [Abstract] [Full Text] [PDF]

				J. A. Berti, A. C. Casquero, P. R. Patricio, E. J. B. Bighetti, E. M. Carneiro, A. C. Boschero, and H. C. F. Oliveira Cholesteryl ester transfer protein expression is down-regulated in hyperinsulinemic transgenic mice J. Lipid Res., October 1, 2003; 44(10): 1870 - 1876. [Abstract] [Full Text] [PDF]

				A. Soro, M. Jauhiainen, C. Ehnholm, and M.-R. Taskinen Determinants of low HDL levels in familial combined hyperlipidemia J. Lipid Res., August 1, 2003; 44(8): 1536 - 1544. [Abstract] [Full Text] [PDF]

				W. Le Goff, M. Guerin, L. Petit, M. J. Chapman, and J. Thillet Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37 J. Lipid Res., July 1, 2003; 44(7): 1322 - 1331. [Abstract] [Full Text] [PDF]

				W. Le Goff, M. Guerin, M. J. Chapman, and J. Thillet A CYP7A promoter binding factor site and Alu repeat in the distal promoter region are implicated in regulation of human CETP gene expression J. Lipid Res., May 1, 2003; 44(5): 902 - 910. [Abstract] [Full Text] [PDF]

				F. V. van Venrooij, R. P. Stolk, J.-D. Banga, T. P. Sijmonsma, A. van Tol, D. W. Erkelens, and G. M. Dallinga-Thie Common Cholesteryl Ester Transfer Protein Gene Polymorphisms and the Effect of Atorvastatin Therapy in Type 2 Diabetes Diabetes Care, April 1, 2003; 26(4): 1216 - 1223. [Abstract] [Full Text] [PDF]

				P. J. Barter, H. B. Brewer Jr, M. J. Chapman, C. H. Hennekens, D. J. Rader, and A. R. Tall Cholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis Arterioscler Thromb Vasc Biol, February 1, 2003; 23(2): 160 - 167. [Abstract] [Full Text] [PDF]

				P. M. Cazita, J. A. Berti, C. Aoki, M. Gidlund, L. M. Harada, V. S. Nunes, E. C. R. Quintao, and H. C. F. Oliveira Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice J. Lipid Res., January 1, 2003; 44(1): 33 - 40. [Abstract] [Full Text] [PDF]

				C.-a. Wu, M. Tsujita, K. Okumura-Noji, S. Usui, H. Kakuuchi, M. Okazaki, and S. Yokoyama Cholesteryl Ester Transfer Protein Expressed in Lecithin Cholesterol Acyltransferase-Deficient Mice Arterioscler Thromb Vasc Biol, August 1, 2002; 22(8): 1347 - 1353. [Abstract] [Full Text] [PDF]

				R. E. Morton, V. Nunes, L. Izem, and E. Quintao Markedly Elevated Lipid Transfer Inhibitor Protein in Hypercholesterolemic Subjects Is Mitigated by Plasma Triglyceride Levels Arterioscler Thromb Vasc Biol, October 1, 2001; 21(10): 1642 - 1649. [Abstract] [Full Text] [PDF]

				M. Guerin, W. Le Goff, T. S. Lassel, A. Van Tol, G. Steiner, and M. J. Chapman Proatherogenic Role of Elevated CE Transfer From HDL to VLDL1 and Dense LDL in Type 2 Diabetes : Impact of the Degree of Triglyceridemia Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 282 - 288. [Abstract] [Full Text] [PDF]

				S. Jansen, J. Lopez-Miranda, P. Castro, F. Lopez-Segura, C. Marin, J. M Ordovas, E. Paz, J. Jimenez-Pereperez, F. Fuentes, and F. Perez-Jimenez Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men Am. J. Clinical Nutrition, July 1, 2000; 72(1): 36 - 41. [Abstract] [Full Text] [PDF]

				A. R. Tall, X.-c. Jiang, Y. Luo, and D. Silver 1999 George Lyman Duff Memorial Lecture : Lipid Transfer Proteins, HDL Metabolism, and Atherogenesis Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1185 - 1188. [Abstract] [Full Text] [PDF]

				M. Guerin, T. S. Lassel, W. Le Goff, M. Farnier, and M. J. Chapman Action of Atorvastatin in Combined Hyperlipidemia : Preferential Reduction of Cholesteryl Ester Transfer From HDL to VLDL1 Particles Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 189 - 197. [Abstract] [Full Text] [PDF]

				L. Berglund, E. H Oliver, N. Fontanez, S. Holleran, K. Matthews, P. S Roheim, H. N Ginsberg, R. Ramakrishnan, and M. Lefevre HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects Am. J. Clinical Nutrition, December 1, 1999; 70(6): 992 - 1000. [Abstract] [Full Text] [PDF]

				C. Desrumaux, A. Athias, G. Bessede, B. Verges, M. Farnier, L. Persegol, P. Gambert, and L. Lagrost Mass Concentration of Plasma Phospholipid Transfer Protein in Normolipidemic, Type IIa Hyperlipidemic, Type IIb Hyperlipidemic, and Non–Insulin-Dependent Diabetic Subjects as Measured by a Specific ELISA Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 266 - 275. [Abstract] [Full Text] [PDF]

				G. Bittolo-Bon and G. Cazzolato Analytical capillary isotachophoresis of total plasma lipoproteins: a new tool to identify atherogenic low density lipoproteins J. Lipid Res., January 1, 1999; 40(1): 170 - 177. [Abstract] [Full Text]

				J. A. Kuivenhoven, J. W. Jukema, A. H. Zwinderman, P. de Knijff, R. McPherson, A. V.G. Bruschke, K. I. Lie, J. J.P. Kastelein, and The Regression Growth Evaluation Statin Study Grou The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis N. Engl. J. Med., January 8, 1998; 338(2): 86 - 93. [Abstract] [Full Text] [PDF]

				K. C. B. Tan, S. W. M. Shiu, and A. W. C. Kung Plasma Cholesteryl Ester Transfer Protein Activity in Hyper- and Hypothyroidism J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 140 - 143. [Abstract] [Full Text]

				T. S. Lassel, M. Guerin, S. Auboiron, M. J. Chapman, and B. Guy-Grand Preferential Cholesteryl Ester Acceptors Among Triglyceride-Rich Lipoproteins During Alimentary Lipemia in Normolipidemic Subjects Arterioscler Thromb Vasc Biol, January 1, 1998; 18(1): 65 - 74. [Abstract] [Full Text] [PDF]

				S. Braschi, D. Masson, G. Rostoker, E. Florentin, A. Athias, C. Martin, B. Jacotot, P. Gambert, C. Lallemant, and L. Lagrost Role of Lipoprotein-Bound NEFAs in Enhancing the Specific Activity of Plasma CETP in the Nephrotic Syndrome Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2559 - 2567. [Abstract] [Full Text]

				R. E. Morton and D. J. Greene Suppression of Lipid Transfer Inhibitor Protein Activity by Oleate : A Novel Mechanism of Cholesteryl Ester Transfer Protein Regulation by Plasma Free Fatty Acids Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 3041 - 3048. [Abstract] [Full Text]

				Y. Huang, S. W. Schwendner, S. C. Rall Jr., D. A. Sanan, and R. W. Mahley Apolipoprotein E2 Transgenic Rabbits. MODULATION OF THE TYPE III HYPERLIPOPROTEINEMIC PHENOTYPE BY ESTROGEN AND OCCURRENCE OF SPONTANEOUS ATHEROSCLEROSIS J. Biol. Chem., September 5, 1997; 272(36): 22685 - 22694. [Abstract] [Full Text] [PDF]

				A. P. Serdyuk and R. E. Morton Lipid Transfer Inhibitor Protein Activity Deficiency in Normolipidemic Uremic Patients on Continuous Ambulatory Peritoneal Dialysis Arterioscler Thromb Vasc Biol, September 1, 1997; 17(9): 1716 - 1724. [Abstract] [Full Text]

				J. A. Kuivenhoven, P. de Knijff, J. M.A. Boer, H. A. Smalheer, G.-J. Botma, J. C. Seidell, J. J.P. Kastelein, and P. H. Pritchard Heterogeneity at the CETP Gene Locus : Influence on Plasma CETP Concentrations and HDL Cholesterol Levels Arterioscler Thromb Vasc Biol, March 1, 1997; 17(3): 560 - 568. [Abstract] [Full Text]

				F. Tato, G. L. Vega, and S. M. Grundy Determinants of Plasma HDL-Cholesterol in Hypertriglyceridemic Patients: Role of Cholesterol-Ester Transfer Protein and Lecithin Cholesteryl Acyl Transferase Arterioscler Thromb Vasc Biol, January 1, 1997; 17(1): 56 - 63. [Abstract] [Full Text]

				R. McPherson, P. Lau, P. Kussie, H. Barrett, and A. R. Tall Plasma Kinetics of Cholesteryl Ester Transfer Protein in the Rabbit: Effects of Dietary Cholesterol Arterioscler Thromb Vasc Biol, January 1, 1997; 17(1): 203 - 210. [Abstract] [Full Text]

				H. C.F. Oliveira, R. A. Chouinard, L. B. Agellon, C. Bruce, L. Ma, A. Walsh, J. L. Breslow, and A. R. Tall Human Cholesteryl Ester Transfer Protein Gene Proximal Promoter Contains Dietary Cholesterol Positive Responsive Elements and Mediates Expression in Small Intestine and Periphery While Predominant Liver and Spleen Expression Is Controlled by 5'-distal Sequences. CIS-ACTING SEQUENCES MAPPED IN TRANSGENIC MICE J. Biol. Chem., December 13, 1996; 271(50): 31831 - 31838. [Abstract] [Full Text] [PDF]

				B. Foger, A. Ritsch, A. Doblinger, H. Wessels, and J. R. Patsch Relationship of Plasma Cholesteryl Ester Transfer Protein to HDL Cholesterol: Studies in Normotriglyceridemia and Moderate Hypertriglyceridemia Arterioscler Thromb Vasc Biol, December 1, 1996; 16(12): 1430 - 1436. [Abstract] [Full Text]

				R. McPherson, G. Agnani, P. Lau, J.-C. Fruchart, A. D. Edgar, and Y. L. Marcel Role of Lp A-I and Lp A-I/A-II in Cholesteryl Ester Transfer Protein–Mediated Neutral Lipid Transfer: Studies in Normal Subjects and in Hypertriglyceridemic Patients Before and After Fenofibrate Therapy Arterioscler Thromb Vasc Biol, November 1, 1996; 16(11): 1340 - 1346. [Abstract] [Full Text]

				M. Guerin, E. Bruckert, P. J. Dolphin, G. Turpin, and M. J. Chapman Fenofibrate Reduces Plasma Cholesteryl Ester Transfer From HDL to VLDL and Normalizes the Atherogenic, Dense LDL Profile in Combined Hyperlipidemia Arterioscler Thromb Vasc Biol, June 1, 1996; 16(6): 763 - 772. [Abstract] [Full Text]

				T. Murakami, S. Michelagnoli, R. Longhi, G. Gianfranceschi, F. Pazzucconi, L. Calabresi, C. R. Sirtori, and G. Franceschini Triglycerides Are Major Determinants of Cholesterol Esterification/Transfer and HDL Remodeling in Human Plasma Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 1819 - 1828. [Abstract] [Full Text]

				M. Guerin, P. J. Dolphin, C. Talussot, J. Gardette, F. Berthezene, and M. J. Chapman Pravastatin Modulates Cholesteryl Ester Transfer From HDL to ApoB-Containing Lipoproteins and Lipoprotein Subspecies Profile in Familial Hypercholesterolemia Arterioscler Thromb Vasc Biol, September 1, 1995; 15(9): 1359 - 1368. [Abstract] [Full Text]

				F. Tato, G. L. Vega, A. R. Tall, and S. M. Grundy Relation Between Cholesterol Ester Transfer Protein Activities and Lipoprotein Cholesterol in Patients With Hypercholesterolemia and Combined Hyperlipidemia Arterioscler Thromb Vasc Biol, January 1, 1995; 15(1): 112 - 120. [Abstract] [Full Text]

				F. M. Sacks, R. McPherson, and B. W. Walsh Effect of Postmenopausal Estrogen Replacement on Plasma Lp(a) Lipoprotein Concentrations Arch Intern Med, May 23, 1994; 154(10): 1106 - 1110. [Abstract] [PDF]

				L. Izem and R. E. Morton Cholesteryl Ester Transfer Protein Biosynthesis and Cellular Cholesterol Homeostasis Are Tightly Interconnected J. Biol. Chem., July 6, 2001; 276(28): 26534 - 26541. [Abstract] [Full Text] [PDF]