Arteriosclerosis and Thrombosis, Vol 11, 653-662, Copyright © 1991 by American Heart Association

ARTICLES

Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease

PH Groot, WA van Stiphout, XH Krauss, H Jansen, A van Tol, E van Ramshorst, S Chin-On, A Hofman, SR Cresswell and L Havekes
Department of Biochemistry, Erasmus University Rotterdam, The Netherlands.

A delayed clearance of postprandial lipoproteins from the plasma may play a role in the etiology of premature coronary atherosclerosis. To address this hypothesis, we studied chylomicron (remnant) metabolism in two groups of 20 selected normolipidemic men aged 35-65 years, a group of coronary artery disease (CAD) patients, and a matched control group with documented minimal coronary atherosclerosis. Subjects received an oral fat load supplemented with cholesterol and retinyl palmitate. Plasma samples obtained during the next 24-hour period were analyzed for total as well as d less than 1.019 g/ml and d greater than 1.019 g/ml triacylglycerol, cholesterol, and retinyl ester concentrations. Although both groups of patients responded identically in terms of the appearance of gut-derived lipids in the plasma, CAD patients showed a marked delay in the clearance of retinyl esters as well as in the normalization of plasma triacylglycerol concentrations. Postheparin plasma hepatic lipase activity was significantly lower in the CAD group. Apolipoprotein E phenotype measurements did not reveal marked differences in frequency between both groups. The frequency distribution was not unusual in comparison with the normal Dutch population. The magnitude of the postprandial responses of triacylglycerol and retinyl esters was correlated positively with the fasting levels of plasma triacylglycerol and negatively with high density lipoprotein subfraction 2 cholesterol concentrations. These data indicate that the clearance of postprandial lipoproteins in normolipidemic CAD patients as selected in the present study is delayed as compared with that of controls without coronary atherosclerosis and suggest that postprandial lipoproteins may play a role in the etiology of their disease.

This article has been cited by other articles:

				G. Reyes-Soffer, S. Holleran, W. Karmally, C. I. Ngai, N.-T. Chen, M. Torres, R. Ramakrishnan, W. S. Blaner, L. Berglund, H. N. Ginsberg, et al. Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus J. Lipid Res., September 1, 2009; 50(9): 1901 - 1909. [Abstract] [Full Text] [PDF]

				S. J. Hernandez Vallejo, M. Alqub, S. Luquet, C. Cruciani-Guglielmacci, P. Delerive, J.-M. Lobaccaro, A.-D. Kalopissis, J. Chambaz, M. Rousset, and J.-M. Lacorte Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet Am J Physiol Gastrointest Liver Physiol, April 1, 2009; 296(4): G782 - G792. [Abstract] [Full Text] [PDF]

				E. Olano-Martin, E. C. Abraham, R. Gill-Garrison, A. M. Valdes, K. Grimaldi, F. Tang, K. G. Jackson, C. M. Williams, and A. M. Minihane Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender J. Lipid Res., May 1, 2008; 49(5): 945 - 953. [Abstract] [Full Text] [PDF]

				P. Perez-Martinez, N. Yiannakouris, J. Lopez-Miranda, D. Arnett, M. Tsai, E. Galan, R. Straka, J. Delgado-Lista, M. Province, J. Ruano, et al. Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations Am. J. Clinical Nutrition, March 1, 2008; 87(3): 744 - 752. [Abstract] [Full Text] [PDF]

				B. Fagerberg, H. Schuster, G. S. Birketvedt, S. Tonstad, K. P. Ohman, and I. Gause-Nilsson Improvement of postprandial lipid handling and glucose tolerance in a non-diabetic population by the dual PPAR{alpha}/{gamma} agonist, tesaglitazar Diabetes and Vascular Disease Research, September 1, 2007; 4(3): 174 - 180. [Abstract] [PDF]

				A. Pocathikorn, R. R. Taylor, I. James, and C. D. S. Mamotte LDL-Receptor mRNA Expression in Men Is Downregulated within an Hour of an Acute Fat Load and Is Influenced by Genetic Polymorphism J. Nutr., September 1, 2007; 137(9): 2062 - 2067. [Abstract] [Full Text] [PDF]

				R. B. Heath, F. Karpe, R. W. Milne, G. C. Burdge, S. A. Wootton, and K. N. Frayn Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E732 - E739. [Abstract] [Full Text] [PDF]

				N. D. Knuth and J. F. Horowitz The Elevation of Ingested Lipids within Plasma Chylomicrons Is Prolonged in Men Compared with Women J. Nutr., June 1, 2006; 136(6): 1498 - 1503. [Abstract] [Full Text] [PDF]

				T. B. Cesar, M. R. M. Oliveira, C. H. Mesquita, and R. C. Maranhao High Cholesterol Intake Modifies Chylomicron Metabolism in Normolipidemic Young Men J. Nutr., April 1, 2006; 136(4): 971 - 976. [Abstract] [Full Text] [PDF]

				N. S. Raikwar, W. K. Cho, R. F. Bowen, and M. A. Deeg Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E463 - E470. [Abstract] [Full Text] [PDF]

				P. Wanby, P. Palmquist, L. Brudin, and M. Carlsson Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis Vascular Medicine, May 1, 2005; 10(2): 103 - 108. [Abstract] [PDF]

				J. P.H. van Wijk, E. J.P. de Koning, M. Castro Cabezas, and T. J. Rabelink Rosiglitazone Improves Postprandial Triglyceride and Free Fatty Acid Metabolism in Type 2 Diabetes Diabetes Care, April 1, 2005; 28(4): 844 - 849. [Abstract] [Full Text] [PDF]

				J. H. Stein, M. A. Merwood, J. B. Bellehumeur, P. E. McBride, D. A. Wiebe, and J. M. Sosman Postprandial Lipoprotein Changes in Patients Taking Antiretroviral Therapy for HIV Infection Arterioscler Thromb Vasc Biol, February 1, 2005; 25(2): 399 - 405. [Abstract] [Full Text] [PDF]

				M E Tushuizen, M Diamant, and R J Heine Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes Postgrad. Med. J., January 1, 2005; 81(951): 1 - 6. [Abstract] [Full Text] [PDF]

				J. S. Perona, J. Martinez-Gonzalez, J. M. Sanchez-Dominguez, L. Badimon, and V. Ruiz-Gutierrez The Unsaponifiable Fraction of Virgin Olive Oil in Chylomicrons from Men Improves the Balance between Vasoprotective and Prothrombotic Factors Released by Endothelial Cells J. Nutr., December 1, 2004; 134(12): 3284 - 3289. [Abstract] [Full Text] [PDF]

				B.-H. Chung, B. S. Cho, P. Liang, S. Doran, L. Osterlund, R. A Oster, B. Darnell, and F. Franklin Contribution of postprandial lipemia to the dietary fat-mediated changes in endogenous lipoprotein-cholesterol concentrations in humans Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1145 - 1158. [Abstract] [Full Text] [PDF]

				S. Santamarina-Fojo, H. Gonzalez-Navarro, L. Freeman, E. Wagner, and Z. Nong Hepatic Lipase, Lipoprotein Metabolism, and Atherogenesis Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1750 - 1754. [Abstract] [Full Text] [PDF]

				J. Lopez-Miranda, G. Cruz, P. Gomez, C. MarIn, E. Paz, P. Perez-MartInez, F. J. Fuentes, J. M. Ordovas, and F. Perez-Jimenez The Influence of Lipoprotein Lipase Gene Variation on Postprandial Lipoprotein Metabolism J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4721 - 4728. [Abstract] [Full Text] [PDF]

				B.-H. Chung, P. Liang, S. Doran, B. H. S. Cho, and F. Franklin Postprandial chylomicrons: potent vehicles for transporting cholesterol from endogenous LDL+HDL and cell membranes to the liver via LCAT and CETP J. Lipid Res., July 1, 2004; 45(7): 1242 - 1255. [Abstract] [Full Text] [PDF]

				F. M. Maggi, S. Raselli, L. Grigore, L. Redaelli, S. Fantappie, and A. L. Catapano Lipoprotein Remnants and Endothelial Dysfunction in the Postprandial Phase J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2946 - 2950. [Abstract] [Full Text] [PDF]

				K. V. Batt, M. Avella, E. H. Moore, B. Jackson, K. E. Suckling, and K. M. Botham Differential Effects of Low-Density Lipoprotein and Chylomicron Remnants on Lipid Accumulation in Human Macrophages Experimental Biology and Medicine, June 1, 2004; 229(6): 528 - 537. [Abstract] [Full Text] [PDF]

				T.B. Twickler, G.M. Dallinga-Thie, J.S. Cohn, and M.J. Chapman Elevated Remnant-Like Particle Cholesterol Concentration: A Characteristic Feature of the Atherogenic Lipoprotein Phenotype Circulation, April 27, 2004; 109(16): 1918 - 1925. [Full Text] [PDF]

				J. A. Moreno, J. Lopez-Miranda, C. Marin, P. Gomez, P. Perez-Martinez, F. Fuentes, R. A. Fernandez de la Puebla, J. A. Paniagua, J. M. Ordovas, and F. Perez-Jimenez The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males J. Lipid Res., November 1, 2003; 44(11): 2059 - 2064. [Abstract] [Full Text] [PDF]

				S. D. Proctor and J. C.L. Mamo Intimal Retention of Cholesterol Derived From Apolipoprotein B100- and Apolipoprotein B48-Containing Lipoproteins in Carotid Arteries of Watanabe Heritable Hyperlipidemic Rabbits Arterioscler Thromb Vasc Biol, September 1, 2003; 23(9): 1595 - 1600. [Abstract] [Full Text] [PDF]

				K. M. Botham, X. Zheng, M. Napolitano, M. Avella, C. Cavallari, R. Rivabene, and E. Bravo The Effects of Dietary n-3 Polyunsaturated Fatty Acids Delivered in Chylomicron Remnants on the Transcription of Genes Regulating Synthesis and Secretion of Very-Low-Density Lipoprotein by the Liver: Modulation by Cellular Oxidative State Experimental Biology and Medicine, February 1, 2003; 228(2): 143 - 151. [Abstract] [Full Text] [PDF]

				D. S. Petitt, S. A. Arngrimsson, and K. J. Cureton Effect of resistance exercise on postprandial lipemia J Appl Physiol, February 1, 2003; 94(2): 694 - 700. [Abstract] [Full Text] [PDF]

				Y. Somekawa, H. Umeki, K. Kobayashi, S. Tomura, T. Aso, and H. Hamaguchi Effects of Hormone Replacement Therapy and Hepatic Lipase Polymorphism on Serum Lipid Profiles in Postmenopausal Japanese Women J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4766 - 4770. [Abstract] [Full Text] [PDF]

				H. Jansen, A. J. M. Verhoeven, and E. J. G. Sijbrands Hepatic lipase: a pro- or anti-atherogenic protein? J. Lipid Res., September 1, 2002; 43(9): 1352 - 1362. [Abstract] [Full Text] [PDF]

				C. Marin, J. Lopez-Miranda, P. Gomez, E. Paz, P. Perez-Martinez, F. Fuentes, J. A. Jimenez-Pereperez, J. M. Ordovas, and F. Perez-Jimenez Effects of the human apolipoprotein A-I promoter G-A mutation on postprandial lipoprotein metabolism Am. J. Clinical Nutrition, August 1, 2002; 76(2): 319 - 325. [Abstract] [Full Text] [PDF]

				A. Ceriello, L. Quagliaro, B. Catone, R. Pascon, M. Piazzola, B. Bais, G. Marra, L. Tonutti, C. Taboga, and E. Motz Role of Hyperglycemia in Nitrotyrosine Postprandial Generation Diabetes Care, August 1, 2002; 25(8): 1439 - 1443. [Abstract] [Full Text] [PDF]

				T. Hozumi, M. Eisenberg, K. Sugioka, A. R. Kokkirala, H. Watanabe, M. Teragaki, J. Yoshikawa, and S. Homma Change in Coronary Flow Reserve on Transthoracic Doppler Echocardiography after a Single High-Fat Meal in Young Healthy Men Ann Intern Med, April 2, 2002; 136(7): 523 - 528. [Abstract] [Full Text] [PDF]

				A. H. Lichtenstein, L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkila, C. Ehnholm, J. Frohlich, and E. J. Schaefer Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects J. Lipid Res., February 1, 2002; 43(2): 264 - 273. [Abstract] [Full Text] [PDF]

				K. A. Dugi, K. Brandauer, N. Schmidt, B. Nau, J. G. Schneider, S. Mentz, T. Keiper, J. R. Schaefer, C. Meissner, H. Kather, et al. Low Hepatic Lipase Activity Is a Novel Risk Factor for Coronary Artery Disease Circulation, December 18, 2001; 104(25): 3057 - 3062. [Abstract] [Full Text] [PDF]

				B. Verges, B. Guerci, V. Durlach, C. Galland-Jos, J. L. Paul, L. Lagrost, and P. Gambert Increased plasma apoA-IV level is a marker of abnormal postprandial lipemia: a study in normoponderal and obese subjects J. Lipid Res., December 1, 2001; 42(12): 2021 - 2029. [Abstract] [Full Text] [PDF]

				H.-S. Kim, F. Abbasi, C. Lamendola, T. McLaughlin, and G. M Reaven Effect of insulin resistance on postprandial elevations of remnant lipoprotein concentrations in postmenopausal women Am. J. Clinical Nutrition, November 1, 2001; 74(5): 592 - 595. [Abstract] [Full Text] [PDF]

				T. J. Tittelbach and R. D. Mattes Oral Stimulation Influences Postprandial Triacylglycerol Concentrations in Humans: Nutrient Specificity J. Am. Coll. Nutr., October 1, 2001; 20(5): 485 - 493. [Abstract] [Full Text] [PDF]

				C.J.M. Halkes, H. van Dijk, P.P.T. de Jaegere, H.W.M. Plokker, Y. van der Helm, D. W. Erkelens, and M. Castro Cabezas Postprandial Increase of Complement Component 3 in Normolipidemic Patients With Coronary Artery Disease: Effects of Expanded-Dose Simvastatin Arterioscler Thromb Vasc Biol, September 1, 2001; 21(9): 1526 - 1530. [Abstract] [Full Text] [PDF]

				L. D. Monti, S. Allibardi, P. M. Piatti, G. Valsecchi, S. Costa, G. Pozza, S. Chierchia, and M. Samaja Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1122 - H1130. [Abstract] [Full Text] [PDF]

				J. P. van Wijk, M. C. Cabezas, C. J. Halkes, and D W. Erkelens Effects of different nutrient intakes on daytime triacylglycerolemia in healthy, normolipemic, free-living men Am. J. Clinical Nutrition, August 1, 2001; 74(2): 171 - 178. [Abstract] [Full Text] [PDF]

				P. J. Nestel, H. Shige, S. Pomeroy, M. Cehun, and J. Chin-Dusting Post-prandial remnant lipids impair arterial compliance J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1929 - 1935. [Abstract] [Full Text] [PDF]

				T. Tholstrup, B. Sandstrom, A. Bysted, and G. Holmer Effect of 6 dietary fatty acids on the postprandial lipid profile, plasma fatty acids, lipoprotein lipase, and cholesterol ester transfer activities in healthy young men Am. J. Clinical Nutrition, February 1, 2001; 73(2): 198 - 208. [Abstract] [Full Text] [PDF]

				A. R. Sharrett, G. Heiss, L. E. Chambless, E. Boerwinkle, S. A. Coady, A. R. Folsom, and W. Patsch Metabolic and Lifestyle Determinants of Postprandial Lipemia Differ From Those of Fasting Triglycerides : The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 275 - 281. [Abstract] [Full Text] [PDF]

				R. D. Santos, L. I. Ventura, A. C. Sposito, R. Schreiber, J. A.F. Ramires, and R. C. Maranhao The effects of gemfibrozil upon the metabolism of chylomicron-like emulsions in patients with endogenous hypertriglyceridemia Cardiovasc Res, February 1, 2001; 49(2): 456 - 465. [Abstract] [Full Text] [PDF]

				R. Abia, Y. M. Pacheco, J. S. Perona, E. Montero, F. J. G. Muriana, and V. Ruiz-Gutiérrez The Metabolic Availability of Dietary Triacylglycerols from Two High Oleic Oils during the Postprandial Period Does Not Depend on the Amount of Oleic Acid Ingested by Healthy Men J. Nutr., January 1, 2001; 131(1): 59 - 65. [Abstract] [Full Text]

				H. Relas, H. Gylling, R. A. Rajaratnam, and T. A. Miettinen Postprandial Retinyl Palmitate and Squalene Metabolism Is Age Dependent J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2000; 55(11): 515B - 521. [Abstract] [Full Text]

				J. A Lovegrove, A. Clohessy, H. Milon, and C. M Williams Modest doses of {beta}-glucan do not reduce concentrations of potentially atherogenic lipoproteins Am. J. Clinical Nutrition, July 1, 2000; 72(1): 49 - 55. [Abstract] [Full Text] [PDF]

				A. J. M. Verhoeven, B. P. Neve, and H. Jansen Intracellular Activation of Rat Hepatic Lipase Requires Transport to the Golgi Compartment and Is Associated with a Decrease in Sedimentation Velocity J. Biol. Chem., March 24, 2000; 275(13): 9332 - 9339. [Abstract] [Full Text] [PDF]

				P. Couture, J. D. Otvos, L. A. Cupples, C. Lahoz, P. W. F. Wilson, E. J. Schaefer, and J. M. Ordovas Association of the C-514T Polymorphism in the Hepatic Lipase Gene With Variations in Lipoprotein Subclass Profiles : The Framingham Offspring Study Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 815 - 822. [Abstract] [Full Text] [PDF]

				J. M. Gill and A. E Hardman Postprandial lipemia: effects of exercise and restriction of energy intake compared1 Am. J. Clinical Nutrition, February 1, 2000; 71(2): 465 - 471. [Abstract] [Full Text] [PDF]

				C. Luley, G. Ronquist, W. Reuter, V. Paal, H.-D. Gottschling, S. Westphal, G. L. King, S. J.L. Bakker, R. J. Heine, and A. Hattemer Point-of-Care Testing of Triglycerides: Evaluation of the Accutrend Triglycerides System Clin. Chem., February 1, 2000; 46(2): 287 - 291. [Full Text] [PDF]

				K. G Jackson, A. Zampelas, J. M. Knapper, H. M Roche, M. J Gibney, A. Kafatos, B. J Gould, J. W Wright, and C. M Williams Differences in glucose-dependent insulinotrophic polypeptide hormone and hepatic lipase in subjects of southern and northern Europe: implications for postprandial lipemia Am. J. Clinical Nutrition, January 1, 2000; 71(1): 13 - 20. [Abstract] [Full Text] [PDF]

				H. M Roche and M. J Gibney Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism1 Am. J. Clinical Nutrition, January 1, 2000; 71(1): 232S - 237S. [Abstract] [Full Text] [PDF]

				F. Abbasi, T. McLaughlin, C. Lamendola, H. Yeni-Komshian, A. Tanaka, T. Wang, K. Nakajima, and G. M. Reaven Fasting Remnant Lipoprotein Cholesterol and Triglyceride Concentrations Are Elevated in Nondiabetic, Insulin-Resistant, Female Volunteers J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 3903 - 3906. [Abstract] [Full Text]

				A. P. van Beek, F. C. de Ruijter-Heijstek, D. W. Erkelens, and T. W. A. de Bruin Menopause Is Associated With Reduced Protection From Postprandial Lipemia Arterioscler Thromb Vasc Biol, November 1, 1999; 19(11): 2737 - 2741. [Abstract] [Full Text] [PDF]

				J. S. Cohn, C. Marcoux, and J. Davignon Detection, Quantification, and Characterization of Potentially Atherogenic Triglyceride-Rich Remnant Lipoproteins Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2474 - 2486. [Abstract] [Full Text] [PDF]

				S. Hadjadj, J.-L. Paul, L. Meyer, V. Durlach, B. Vergès, O. Ziegler, P. Drouin, and B. Guerci Delayed Changes in Postprandial Lipid in Young Normolipidemic Men after a Nocturnal Vitamin A Oral Fat Load Test J. Nutr., September 1, 1999; 129(9): 1649 - 1655. [Abstract] [Full Text]

				S. Boquist, G. Ruotolo, R. Tang, J. Bjorkegren, M. G. Bond, U. de Faire, F. Karpe, and A. Hamsten Alimentary Lipemia, Postprandial Triglyceride-Rich Lipoproteins, and Common Carotid Intima-Media Thickness in Healthy, Middle-Aged Men Circulation, August 17, 1999; 100(7): 723 - 728. [Abstract] [Full Text] [PDF]

				R. V. Shohet, G. L. Vega, A. Anwar, J. E. Cigarroa, S. M. Grundy, and J. C. Cohen Hepatic Lipase (LIPC) Promoter Polymorphism in Men With Coronary Artery Disease : Allele Frequency and Effects on Hepatic Lipase Activity and Plasma HDL-C Concentrations Arterioscler Thromb Vasc Biol, August 1, 1999; 19(8): 1975 - 1978. [Abstract] [Full Text] [PDF]

				M. Weintraub, I. Grosskopf, Y. Trostanesky, G. Charach, A. Rubinstein, and N. Stern Thyroxine Replacement Therapy Enhances Clearance of Chylomicron Remnants in Patients with Hypothyroidism J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2532 - 2536. [Abstract] [Full Text]

				L. F. Tinker, E. J Parks, S. R. Behr, B. O. Schneeman, and P. A. Davis (n-3) Fatty Acid Supplementation in Moderately Hypertriglyceridemic Adults Changes Postprandial Lipid and Apolipoprotein B Responses to a Standardized Test Meal J. Nutr., June 1, 1999; 129(6): 1126 - 1134. [Abstract] [Full Text]

				W. H. F. Sutherland, R. J. Walker, S. A. de Jong, A. M. van Rij, V. Phillips, and H. L. Walker Reduced Postprandial Serum Paraoxonase Activity After a Meal Rich in Used Cooking Fat Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1340 - 1347. [Abstract] [Full Text] [PDF]

				M. J. Singleton, C. Heiser, K. Jamesen, and R. D. Mattes Sweetener Augmentation of Serum Triacylglycerol during a Fat Challenge Test in Humans J. Am. Coll. Nutr., April 1, 1999; 18(2): 179 - 185. [Abstract] [Full Text] [PDF]

				M.-L. M. Gronholdt Ultrasound and Lipoproteins as Predictors of Lipid-Rich, Rupture-Prone Plaques in the Carotid Artery Arterioscler Thromb Vasc Biol, January 1, 1999; 19(1): 2 - 13. [Abstract] [Full Text] [PDF]

				Y. Fujioka, A. D. Cooper, and L. G. Fong Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages J. Lipid Res., December 1, 1998; 39(12): 2339 - 2349. [Abstract] [Full Text]

				M. A. Ostos, J. Lopez-Miranda, J. M. Ordovas, C. Marin, A. Blanco, P. Castro, F. Lopez-Segura, J. Jimenez-Pereperez, and F. Perez-Jimenez Dietary fat clearance is modulated by genetic variation in apolipoprotein A-IV gene locus J. Lipid Res., December 1, 1998; 39(12): 2493 - 2500. [Abstract] [Full Text]

				S. Lemieux, R. Fontani, K. D. Uffelman, G. F. Lewis, and G. Steiner Apolipoprotein B-48 and retinyl palmitate are not equivalent markers of postprandial intestinal lipoproteins J. Lipid Res., October 1, 1998; 39(10): 1964 - 1971. [Abstract] [Full Text]

				B. H. Chung, F. Franklin, B. H. S. Cho, J. P. Segrest, K. Hart, and B. E. Darnell Potencies of Lipoproteins in Fasting and Postprandial Plasma to Accept Additional Cholesterol Molecules Released From Cell Membranes Arterioscler Thromb Vasc Biol, August 1, 1998; 18(8): 1217 - 1230. [Abstract] [Full Text] [PDF]

				M. Orth, M. Hanisch, G. Kroning, M. Porsch-Ozcurumez, H. Wieland, and C. Luley Fluorometric determination of total retinyl esters in triglyceride-rich lipoproteins Clin. Chem., July 1, 1998; 44(7): 1459 - 1465. [Abstract] [Full Text] [PDF]

				A. H. Slyper, S. Zvereva, G. Schectman, R. G. Hoffmann, J. Pleuss, and J. A. Walker Normal Postprandial Lipemia and Chylomicron Clearance in Offspring of Parents with Early Coronary Artery Disease J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1106 - 1113. [Abstract] [Full Text]

				M.-L. M. Gronholdt, B. G. Nordestgaard, B. M. Wiebe, J. E. Wilhjelm, and H. Sillesen Echo-Lucency of Computerized Ultrasound Images of Carotid Atherosclerotic Plaques Are Associated With Increased Levels of Triglyceride-Rich Lipoproteins as Well as Increased Plaque Lipid Content Circulation, January 13, 1998; 97(1): 34 - 40. [Abstract] [Full Text] [PDF]

				N. Xu, B. Dahlback, A.-K. Ohlin, and A. Nilsson Association of Vitamin K–Dependent Coagulation Proteins and C4b Binding Protein With Triglyceride-Rich Lipoproteins of Human Plasma Arterioscler Thromb Vasc Biol, January 1, 1998; 18(1): 33 - 39. [Abstract] [Full Text] [PDF]

				T. S. Lassel, M. Guerin, S. Auboiron, M. J. Chapman, and B. Guy-Grand Preferential Cholesteryl Ester Acceptors Among Triglyceride-Rich Lipoproteins During Alimentary Lipemia in Normolipidemic Subjects Arterioscler Thromb Vasc Biol, January 1, 1998; 18(1): 65 - 74. [Abstract] [Full Text] [PDF]

				K. Kagawa, H. Matsutaka, C. Fukuhama, H. Fujino, and H. Okuda Suppressive Effect of Globin Digest on Postprandial Hyperlipidemia in Male Volunteers J. Nutr., January 1, 1998; 128(1): 56 - 60. [Abstract] [Full Text]

				P. Marckmann, E.-M. Bladbjerg, and J. Jespersen Dietary Fish Oil (4 g Daily) and Cardiovascular Risk Markers in Healthy Men Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3384 - 3391. [Abstract] [Full Text]

				H. Jansen, A. J. M. Verhoeven, L. Weeks, J. J. P. Kastelein, D. J. J. Halley, A. van den Ouweland, J. W. Jukema, J. C. Seidell, and J. C. Birkenhager Common C-to-T Substitution at Position -480 of the Hepatic Lipase Promoter Associated With a Lowered Lipase Activity in Coronary Artery Disease Patients Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2837 - 2842. [Abstract] [Full Text]

				N. Mero, M. Syvanne, B. Eliasson, U. Smith, and M.-R. Taskinen Postprandial Elevation of ApoB-48-Containing Triglyceride-Rich Particles and Retinyl Esters in Normolipemic Males Who Smoke Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2096 - 2102. [Abstract] [Full Text]

				J. Lopez-Miranda, J.M. Ordovas, M.A. Ostos, C. Marin, S. Jansen, J. Salas, A. Blanco-Molina, J.A. Jimenez-Pereperez, F. Lopez-Segura, and F. Perez-Jimenez Dietary Fat Clearance in Normal Subjects Is Modulated by Genetic Variation at the Apolipoprotein B Gene Locus Arterioscler Thromb Vasc Biol, September 1, 1997; 17(9): 1765 - 1773. [Abstract] [Full Text]

				J. C. Rutledge, M. M. Woo, A. A. Rezai, L. K. Curtiss, and I. J. Goldberg Lipoprotein Lipase Increases Lipoprotein Binding to the Artery Wall and Increases Endothelial Layer Permeability by Formation of Lipolysis Products Circ. Res., June 19, 1997; 80(6): 819 - 828. [Abstract] [Full Text]

				M.-L. M. Gronholdt, B. G. Nordestgaard, T. G. Nielsen, and H. Sillesen Echolucent Carotid Artery Plaques Are Associated With Elevated Levels of Fasting and Postprandial Triglyceride-Rich Lipoproteins Stroke, December 1, 1996; 27(12): 2166 - 2172. [Abstract] [Full Text]

				M. S Weintraub, I. Grosskopf, T. Rassin, H. Miller, G. Charach, H. H Rotmensch, M. Liron, A. Rubinstein, and A. Iaina Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years BMJ, April 13, 1996; 312(7036): 935 - 939. [Abstract] [Full Text]

				A. R. Sharrett, L. E. Chambless, G. Heiss, C. C. Paton, and W. Patsch Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Asymptomatic Carotid Artery Atherosclerosis in Middle-aged Men and Women : The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, December 1, 1995; 15(12): 2122 - 2129. [Abstract] [Full Text]

				H. Bernardes-Silva, O. Toffoletto, L. A. Bortolotto, M. C.M. Latrilha, E. M. Krieger, F. Pileggi, and R. C. Maranhao Malignant Hypertension Is Accompanied by Marked Alterations in Chylomicron Metabolism Hypertension, December 1, 1995; 26(6): 1207 - 1210. [Abstract] [Full Text]

				H. N. Ginsberg, J. Jones, W. S. Blaner, A. Thomas, W. Karmally, L. Fields, D. Blood, and M. D. Begg Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Newly Diagnosed Exercise-Induced Myocardial Ischemia in Middle-Aged Men and Women Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 1829 - 1838. [Abstract] [Full Text]

				P. Tornvall, G. Olivecrona, F. Karpe, A. Hamsten, and T. Olivecrona Lipoprotein Lipase Mass and Activity in Plasma and Their Increase After Heparin Are Separate Parameters With Different Relations to Plasma Lipoproteins Arterioscler Thromb Vasc Biol, August 1, 1995; 15(8): 1086 - 1093. [Abstract] [Full Text]

				J. Jeppesen, C. B. Hollenbeck, M.-Y. Zhou, A. M. Coulston, C. Jones, Y.-D. I. Chen, and G. M. Reaven Relation Between Insulin Resistance, Hyperinsulinemia, Postheparin Plasma Lipoprotein Lipase Activity, and Postprandial Lipemia Arterioscler Thromb Vasc Biol, March 1, 1995; 15(3): 320 - 324. [Abstract] [Full Text]