Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1991;11:517-529

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hadcock, S.
Right arrow Articles by Hatton, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hadcock, S.
Right arrow Articles by Hatton, M. W.

Arteriosclerosis and Thrombosis, Vol 11, 517-529, Copyright © 1991 by American Heart Association

ARTICLES

Intimal alterations in rabbit aortas during the first 6 months of alloxan-induced diabetes

S Hadcock, M Richardson, PD Winocour and MW Hatton
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.

Diabetes mellitus is a major risk factor for atherosclerosis. Since endothelial alteration is probably associated with the development of atherosclerosis, we questioned whether morphological evidence of endothelial injury could be observed during the first 6 months of diabetes induced by a single intravenous injection of alloxan in normally fed rabbits compared with age-matched controls. Diabetes (plasma glucose greater than 16 mM) was established by 5 days after alloxan injection. Endothelial alterations consistent with injury, including adhesion of white blood cells, platelets, and fibrin-like material to the endothelial surface, were seen in diabetic rabbit aortas by 2 weeks. These alterations became more severe during the next 6 months. Increased endothelial replication in diabetic vessels was shown by the uptake of tritium-labeled thymidine at 2 weeks and at 3 and 6 months. Hyperplasia of intimal smooth muscle cells progressed during 3 months after treatment. About one third of the diabetic rabbits also showed an elevated plasma cholesterol level, which correlated with increased intimal proliferation but not with endothelial injury or replication. The onset of alloxan-induced diabetes in rabbits is associated with nondenuding endothelial injury and subsequent intimal hypertrophy, changes that are consistent with atherogenesis.


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Zhou, L. May, P. Liao, P. L. Gross, and J. I. Weitz
Inferior Vena Cava Ligation Rapidly Induces Tissue Factor Expression and Venous Thrombosis in Rats
Arterioscler Thromb Vasc Biol, June 1, 2009; 29(6): 863 - 869.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
T. J. Stalker, Y. Gong, and R. Scalia
The Calcium-Dependent Protease Calpain Causes Endothelial Dysfunction in Type 2 Diabetes
Diabetes, April 1, 2005; 54(4): 1132 - 1140.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
N. Lamharzi, C. B. Renard, F. Kramer, S. Pennathur, J. W. Heinecke, A. Chait, and K. E. Bornfeldt
Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions: Potential Role of Glucose-Oxidized LDL
Diabetes, December 1, 2004; 53(12): 3217 - 3225.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. A. Vogl-Willis and I. J. Edwards
High Glucose-Induced Alterations in Subendothelial Matrix Perlecan Leads to Increased Monocyte Binding
Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 858 - 863.
[Abstract] [Full Text]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
D. Browne, D. Meeking, K. Shaw, and M. Cummings
Review: Endothelial dysfunction and pre-symptomatic atherosclerosis in type 1 diabetes -- pathogenesis and identification
The British Journal of Diabetes & Vascular Disease, January 1, 2003; 3(1): 27 - 34.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
R. F Ammar Jr., D. D Gutterman, L. A Brooks, and K. C Dellsperger
Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes
Cardiovasc Res, August 18, 2000; 47(3): 595 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. K. Patricia, J. A. Kim, C. M. Harper, P. T. Shih, J. A. Berliner, R. Natarajan, J. L. Nadler, and C. C. Hedrick
Lipoxygenase Products Increase Monocyte Adhesion to Human Aortic Endothelial Cells
Arterioscler Thromb Vasc Biol, November 1, 1999; 19(11): 2615 - 2622.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. S. Tsao, J. Niebauer, R. Buitrago, P. S. Lin, B.-y. Wang, J. P. Cooke, Y-d. Ida Chen, and G. M. Reaven
Interaction of Diabetes and Hypertension on Determinants of Endothelial Adhesiveness
Arterioscler Thromb Vasc Biol, June 1, 1998; 18(6): 947 - 953.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. K. Patricia, R. Natarajan, A. N. Dooley, F. Hernandez, J.-L. Gu, J. A. Berliner, J. J. Rossi, J. L. Nadler, R. S. Meidell, and C. C. Hedrick
Adenoviral Delivery of a Leukocyte-Type 12 Lipoxygenase Ribozyme Inhibits Effects of Glucose and Platelet-Derived Growth Factor in Vascular Endothelial and Smooth Muscle Cells
Circ. Res., April 13, 2001; 88(7): 659 - 665.
[Abstract] [Full Text] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1991 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.