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Arteriosclerosis, Thrombosis, and Vascular Biology. 1991;11:32-38

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Arteriosclerosis and Thrombosis, Vol 11, 32-38, Copyright © 1991 by American Heart Association

ARTICLES

Lipoprotein(a) in diet-induced atherosclerosis in nonhuman primates

RL Nachman, D Gavish, N Azrolan and TB Clarkson
Division of Hematology-Oncology, Cornell University Medical College, New York, NY 10021.

Lipoprotein(a) (Lp[a]) is a low density lipoprotein particle that contains plasminogen-like apolipoprotein(a). Recent studies suggest an association of Lp(a) with atherosclerotic vascular disease. We have studied the accumulation of Lp(a) in atherosclerotic arteries of monkeys with diet-induced atherosclerosis. Immunohistochemistry with monospecific Lp(a) antisera revealed striking accumulations of Lp(a) in atherosclerotic coronary artery lesions. There was no Lp(a) in the normal, nonatherosclerotic arteries. Analysis of paired tissue and serum samples from 17 male hyperlipoproteinemic monkeys revealed a significant correlation between aortic wall Lp(a) and serum Lp(a) levels. The serum cholesterol level failed to correlate with either aortic Lp(a) or serum Lp(a). These results add further evidence for the potential role of Lp(a) in the pathogenesis of atherosclerosis.


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