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Arteriosclerosis, Thrombosis, and Vascular Biology. 1990;10:1026-1031

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Arteriosclerosis, Vol 10, 1026-1031, Copyright © 1990 by American Heart Association

ARTICLES

Relationship between high density lipoprotein subfractions and coronary risk factors in a rural white population

HJ Steenkamp, PL Jooste, AJ Benade, ML Langenhoven and JE Rossouw
Research Institute for Nutritional Diseases, South African Medical Research Council, Tygerberg.

The relationship of serum high density lipoprotein cholesterol (HDL-C) levels and of the HDL2-C and HDL3-C subfractions to several factors associated with coronary risk was examined in a cross-sectional study, which included 655 men and 731 women ages 20 to 64 years. Participants with coronary heart disease (CHD) had lower levels of HDL-C, HDL2-C, and HDL3-C; however, only HDL-C in women was significant. Maleness, body mass index, triglyceride levels, tobacco use, and carbohydrate intake (in men) were significantly inversely related to total HDL-C, while alcohol intake was significantly positively related to HDL-C. The associations were stronger for HDL2-C than for HDL3-C, except that alcohol intake in men was more strongly related to HDL3-C. The findings of this study suggest that several factors that influence CHD risk do so in part through modifying HDL2-C levels.


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