Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1990;10:106-110

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mukodani, J.
Right arrow Articles by Fukuzaki, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mukodani, J.
Right arrow Articles by Fukuzaki, H.

Arteriosclerosis, Vol 10, 106-110, Copyright © 1990 by American Heart Association

ARTICLES

Effects of hypoxia on sterol synthesis, acyl-CoA:cholesterol acyltransferase activity, and efflux of cholesterol in cultured rabbit skin fibroblasts

J Mukodani, Y Ishikawa and H Fukuzaki
First Department of Internal Medicine, Kobe University School of Medicine, Japan.

To elucidate the mechanisms of cholesterol accumulation in cells under hypoxic conditions, we tested the effects of hypoxia on sterol synthesis, on the activity of acyl-CoA:cholesterol acyltransferase (ACAT), and on the efflux of cholesterol in cultured rabbit skin fibroblasts. Sterol synthesis was measured by the incorporation of 14C- acetate into sterol, and ACAT activity, by the incorporation of 14C- oleate into cholesteryl ester. Hypoxia suppressed both sterol synthesis and the efflux of cholesterol but increased ACAT activity. These results suggest that hypoxia disturbs the balance of cholesterol metabolism in cells and induces intracellular lipid accumulation.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. D. Nguyen, J. G. McDonald, R. K. Bruick, and R. A. DeBose-Boyd
Hypoxia Stimulates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase through Accumulation of Lanosterol and Hypoxia-Inducible Factor-mediated Induction of Insigs
J. Biol. Chem., September 14, 2007; 282(37): 27436 - 27446.
[Abstract] [Full Text] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1990 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.