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Arteriosclerosis, Thrombosis, and Vascular Biology
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Arteriosclerosis, Thrombosis, and Vascular Biology. 1981;1:443-448

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Arteriosclerosis, Vol 1, 443-448, Copyright © 1981 by American Heart Association

ARTICLES

Platelet function and survival in patients wit severe hypercholesterolemia

L Corash, J Andersen, BJ Poindexter and EJ Schaefer

Platelet aggregation and survival were measured in twelve subjects with severe hypercholesterolemia. There was a small increase in sensitivity to epinephrine and adenosine diphosphate among the most hypercholesterolemic patients, but this did not correlate with reduced platelet lifespan. Platelet survival was normal or only moderately reduced in the markedly hypercholesterolemic homozygous subjects. However, the incidence of reduced platelet survival was significantly increased (p less than 0.05) among the older patients with more extensive atherosclerotic vascular disease compared to the younger patients with limited vascular disease. Marked hypercholesterolemia in the absence of atherosclerosis does not appear to accelerate platelet destruction, although a modest increased aggregability is present.


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K. Saito, H. Sano, J. Kawahara, and M. Yokoyama
Calcium Supplementation Attenuates an Enhanced Platelet Function in Salt-Loaded Mildly Hypertensive Patients
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[Abstract] [Full Text]


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