Arteriosclerosis, Vol 1, 250-256, Copyright © 1981 by American Heart Association

ARTICLES

Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries. Statistical analysis from the Oslo study

I Holme, SC Enger, A Helgeland, I Hjermann, P Leren, PG Lund-Larsen, LA Solberg and JP Strong

In 1972-1973, about 16,200 men living in Oslo, aged 40 to 49 years, were examined for cardiovascular disease, and had a number of coronary risk factors measured. This report gives the results of 129 autopsied cases with regard to the association between raised atherosclerotic lesions in coronary and cerebral arteries and various coronary risk factors. For coronary raised lesions, the high density lipoprotein (HDL) cholesterol ratio was the most significant risk factor. Systolic blood pressure and total serum cholesterol were also significantly associated. Physical activity at work and at leisure, nonfasting triglycerides, and cigarette smoking did not show a significant association with coronary artery raised lesions. The association between total serum cholesterol and systolic blood indicates that total serum cholesterol may be more important than systolic pressure in the synergism affecting the development of coronary atherosclerosis. For cerebral artery raised lesions, blood pressure was the most important risk factor, even though serum cholesterol was highly associated with the lesions. The interaction analysis also suggested that blood pressure was more important than serum cholesterol in the synergism.

This article has been cited by other articles:

				M. Amato, P. Montorsi, A. Ravani, E. Oldani, S. Galli, P. M. Ravagnani, E. Tremoli, and D. Baldassarre Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings Eur. Heart J., September 1, 2007; 28(17): 2094 - 2101. [Abstract] [Full Text] [PDF]

				M. L. Bots, D. Baldassarre, A. Simon, E. de Groot, D. H. O'Leary, W. Riley, J. J. Kastelein, and D. E. Grobbee Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? Eur. Heart J., February 2, 2007; 28(4): 398 - 406. [Abstract] [Full Text] [PDF]

				G. N. Thomas, J. W. Lin, W. W.M. Lam, B. Tomlinson, V. Yeung, J. C.N. Chan, R. Liu, and K. S. Wong Increasing Severity of Cardiovascular Risk Factors With Increasing Middle Cerebral Artery Stenotic Involvement in Type 2 Diabetic Chinese Patients With Asymptomatic Cerebrovascular Disease Diabetes Care, May 1, 2004; 27(5): 1121 - 1126. [Abstract] [Full Text] [PDF]

				T. Y. Goraya, C. L. Leibson, P. J. Palumbo, S. A. Weston, J. M. Killian, E. A. Pfeifer, S. J. Jacobsen, R. L. Frye, and V.e. L. Roger Coronary atherosclerosis in diabetes mellitus: A population-based autopsy study J. Am. Coll. Cardiol., September 4, 2002; 40(5): 946 - 953. [Abstract] [Full Text] [PDF]

				H. C McGill Jr, C A. McMahan, E. E Herderick, G. T Malcom, R. E Tracy, and J. P Strong Origin of atherosclerosis in childhood and adolescence Am. J. Clinical Nutrition, November 1, 2000; 72 (5): 1307S - 1315S. [Abstract] [Full Text] [PDF]

				P. Sun, K. M. Dwyer, C. N. B. Merz, W. Sun, C. A. Johnson, A. M. Shircore, and J. H. Dwyer Blood Pressure, LDL Cholesterol, and Intima-Media Thickness : A Test of the "Response to Injury" Hypothesis of Atherosclerosis Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 2005 - 2010. [Abstract] [Full Text] [PDF]

				F. Buttitta, U. Limbruno, A. S. Petronio, R. Baglini, G. Strata, R. Mariotti, M. Ciccone, M. Mariani, and A. Balbarini Usefulness of Carotid Intima-Media Thickness Measurement and Peripheral B-Mode Ultrasound Scan in the Clinical Screening of Patients with Coronary Artery Disease Angiology, April 1, 2000; 51(4): 269 - 279. [Abstract] [PDF]

				T. Uehara, M. Tabuchi, T. Hayashi, H. Kurogane, and A. Yamadori Asymptomatic Occlusive Lesions of Carotid and Intracranial Arteries in Japanese Patients With Ischemic Heart Disease : Evaluation by Brain Magnetic Resonance Angiography Stroke, March 1, 1996; 27(3): 393 - 397. [Abstract] [Full Text]

				A. Visona, R. Pesavento, L. Lusiani, A. Bonanome, C. Cernetti, M. Rossi, P. Maiolino, and A. Pagnan Intimal Medial Thickening of Common Carotid Artery as Indicator of Coronary Artery Disease Angiology, January 1, 1996; 47(1): 61 - 66. [Abstract] [PDF]

				M. R. Adams, A. Nakagomi, A. Keech, J. Robinson, R. McCredie, B. P. Bailey, S. B. Freedman, and D. S. Celermajer Carotid Intima-Media Thickness Is Only Weakly Correlated With the Extent and Severity of Coronary Artery Disease Circulation, October 15, 1995; 92(8): 2127 - 2134. [Abstract] [Full Text]

				C. Lemne, T. Jogestrand, and U. de Faire Carotid Intima-Media Thickness and Plaque in Borderline Hypertension Stroke, January 1, 1995; 26(1): 34 - 39. [Abstract] [Full Text]

				M. Nishino, K. Sueyoshi, M. Yasuno, Y. Yamada, H. Abe, M. Hori, and T. Kamada Risk Factors for Carotid Atherosclerosis and Silent Cerebral Infarction in Patients with Coronary Heart Disease Angiology, June 1, 1993; 44(6): 432 - 440. [Abstract] [PDF]

				V. Sanguigni, M. Gallu, and A. Strano Incidence of Carotid Artery Atherosclerosis in Patients with Coronary Artery Disease Angiology, January 1, 1993; 44(1): 34 - 38. [Abstract] [PDF]

				O. Shpilberg, I. Rabi, K. Schiller, R. Walden, D. Harats, K.S. Tyrrell, B. Coller, and U. Seligsohn Patients With Glanzmann Thrombasthenia Lacking Platelet Glycoprotein {alpha}IIb{beta}3 (GPIIb/IIIa) and {alpha}v{beta}3 Receptors Are Not Protected From Atherosclerosis Circulation, March 5, 2002; 105(9): 1044 - 1048. [Abstract] [Full Text] [PDF]