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on March 4, 2004

Arteriosclerosis, Thrombosis, and Vascular Biology. 2004
Published online before print March 4, 2004, doi: 10.1161/01.ATV.zhq0504.0173
A more recent version of this article appeared on May 1, 2004
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Submitted on December 2, 2003
Accepted on February 24, 2004

C-Reactive Protein Is Associated With Arterial Stiffness in Apparently Healthy Individuals

Yasmin ; Carmel M. McEniery ; Sharon Wallace ; Isla S. Mackenzie ; John R. Cockcroft ; and Ian B. Wilkinson *

From the Clinical Pharmacology Unit (Y., C.M.M., S.W., I.S.M., I.B.W.), University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK; and the Department of Cardiology (J.R.C.), University of Wales, College of Medicine, University Hospital, Cardiff, UK.

* To whom correspondence should be addressed. E-mail: ibw20{at}cam.ac.uk.

Objective--C-reactive protein (CRP) levels predict outcome in healthy individuals and patients with atherosclerosis. Arterial stiffness also independently predicts all-cause and cardiovascular mortality and may be involved in the process of atherosclerosis. The aim of this study was to investigate the relationship between stiffness and inflammation in a cohort of healthy individuals.

Methods and Results--Pulse wave velocity (PWV) and blood pressure were assessed in 427 individuals. Subjects with cardiovascular disease, diabetes, hypercholesterolemia and those using medication were excluded. CRP correlated with age, mean arterial pressure (MAP), brachial and aortic PWV, and pulse pressures. In multiple regression models, aortic PWV correlated independently with age, CRP, male gender, and MAP (R=0.593; P<0.001). CRP was also independently associated with brachial PWV. Aortic augmentation index correlated with age, gender, MAP, and inversely with heart rate and height, but not with CRP (R=0.794; P<0.001). Aortic, carotid, and brachial pulse pressures were also independently associated with CRP levels.

Conclusion--Aortic and brachial PWV, and pulse pressure, relate to levels of inflammation in healthy individuals, suggesting that inflammation may be involved in arterial stiffening. Anti-inflammatory strategies may, therefore, be of benefit in reducing arterial stiffness and thus cardiovascular risk, especially in patients with premature arterial stiffening.
Key words: C-reactive protein • pulse wave analysis • augmentation index • pulse wave velocity • inflammation




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